How safe are serotonin reuptake inhibitors for depression in patients with coronary heart disease?
YI Sheline, KE Freedland, RM Carney - The American journal of medicine, 1997 - Elsevier
Depression occurs frequently in patients with coronary heart disease (CHD), and confers
significant risk for additional morbidity and mortality. The cardiac effects of the tricyclic
antidepressants (TCAs) have been well characterized. In contrast, the cardiac effects of the
selective serotonin reuptake inhibitors (SSRIs) have been less thoroughly investigated. The
Medline database from 1986 to 1996 was searched for all reports of cardiac effects of SSRIs,
and this literature is summarized. In addition, potential drug interactions, reports of side …
significant risk for additional morbidity and mortality. The cardiac effects of the tricyclic
antidepressants (TCAs) have been well characterized. In contrast, the cardiac effects of the
selective serotonin reuptake inhibitors (SSRIs) have been less thoroughly investigated. The
Medline database from 1986 to 1996 was searched for all reports of cardiac effects of SSRIs,
and this literature is summarized. In addition, potential drug interactions, reports of side …
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